Department of Pathology and Medical Biology, Section of Immunoendocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, EA11, 9713 GZ, Groningen, The Netherlands.
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Curr Diab Rep. 2018 May 19;18(7):39. doi: 10.1007/s11892-018-1014-4.
Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve transplantation outcomes. This review discusses the current therapeutic strategies to modulate ECM components to improve islet engraftment.
Approaches applied are seeding islets in ECM of decellularized organs, supplementation of specific ECM components in polymeric scaffolds or immunoisolating capsules, and stimulating islet ECM production with specific growth factors or ECM-producing cells. These strategies have shown success in improving functional islet survival. However, the same experiments show that caution should be taken as some ECM components may negatively impact islet function and engraftment. ECM restoration resulted in improved transplantation outcomes, but careful selection of beneficial ECM components and strategies is warranted.
细胞外基质（ECM）成分可调节胰岛细胞间的相互作用。在作为 1 型糖尿病治疗方法的胰岛移植前分离过程中，ECM 会被破坏，从而影响功能移植物的存活。最近，恢复 ECM 的策略已被证明可以改善移植结果。本综述讨论了调节 ECM 成分以改善胰岛移植的当前治疗策略。
应用的方法包括将胰岛接种在脱细胞化器官的 ECM 中、在聚合物支架或免疫隔离胶囊中补充特定的 ECM 成分，以及用特定的生长因子或产生 ECM 的细胞刺激胰岛 ECM 的产生。这些策略已成功改善了功能性胰岛的存活。然而，同样的实验表明，应该谨慎行事，因为一些 ECM 成分可能会对胰岛功能和移植产生负面影响。ECM 的恢复导致了移植结果的改善，但需要仔细选择有益的 ECM 成分和策略。
