Department of Psychology, Indiana University-Purdue University Fort Wayne, Fort Wayne, IN 46805, USA; Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Department of Psychology, Indiana University-Purdue University Fort Wayne, Fort Wayne, IN 46805, USA.
Curr Biol. 2018 Jun 4;28(11):1803-1810.e5. doi: 10.1016/j.cub.2018.04.034. Epub 2018 May 17.
The vestibular system provides a crucial component of place-cell and head-direction cell activity [1-7]. Otolith signals are necessary for head-direction signal stability and associated behavior [8, 9], and the head-direction signal's contribution to parahippocampal spatial representations [10-14] suggests that place cells may also require otolithic information. Here, we demonstrate that self-movement information from the otolith organs is necessary for the development of stable place fields within and across sessions. Place cells in otoconia-deficient tilted mice showed reduced spatial coherence and formed place fields that were located closer to environmental boundaries, relative to those of control mice. These differences reveal an important otolithic contribution to place-cell functioning and provide insight into the cognitive deficits associated with otolith dysfunction.
前庭系统为位置细胞和头朝向细胞活动提供了关键组成部分[1-7]。耳石信号对于头朝向信号的稳定性和相关行为是必要的[8,9]，而且头朝向信号对头旁海马空间表征的贡献[10-14]表明位置细胞也可能需要耳石信息。在这里，我们证明了来自耳石器官的自身运动信息对于在各次实验内和实验间建立稳定的位置场是必要的。与对照组小鼠相比，在耳石缺失倾斜的小鼠中，位置细胞的空间相干性降低，形成的位置场更靠近环境边界。这些差异揭示了耳石对位置细胞功能的重要贡献，并深入了解了与耳石功能障碍相关的认知缺陷。
