从猴头菇液体培养物中得到的三种具有神经营养活性的新石竹烷二萜。
Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus.
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
J Antibiot (Tokyo). 2018 Sep;71(9):818-821. doi: 10.1038/s41429-018-0065-8. Epub 2018 May 21.
Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC of 73.7 μM.
从中国传统药用真菌珊瑚菌（Hericium erinaceus）的液体发酵液中分离得到 3 个新的齿孔烷二萜类化合物 erinacines T-V（1-3），以及 2 个已知的齿孔烷二萜类化合物 erinacine A（4）和 erinacine P（5）。通过广泛的光谱分析确定了 1-3 的结构。所有分离得到的化合物均采用 PC12 细胞系进行了细胞毒性和促进神经突生长活性评价。化合物 1-3 和 5 在 2.5-10 μM 的浓度范围内对 PC12 细胞表现出明显的促进神经突生长作用。化合物 4 对 PC12 细胞表现出较弱的细胞毒性，IC 为 73.7 μM。
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