从 Vladimiria souliei 中分离得到的五个具有潜在神经保护活性的罕见二聚倍半萜。
Five rare dimeric sesquiterpenes exhibiting potential neuroprotection activity from Vladimiria souliei.
机构信息
Guangdong Pharmaceutical University, 280 Waihuan East Road,Panyu District, Guangdong 510006, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
出版信息
Fitoterapia. 2018 Jul;128:192-197. doi: 10.1016/j.fitote.2018.05.022. Epub 2018 May 18.
Two rare C sesquiterpene lactone dimers, vlasouliolides J-K (1-2), together with three C sesquiterpene dimers, vlasoulioliones A-C (3-5), were isolated from Vladimiria souliei. Their chemical structures were elucidated by NMR and MS spectroscopic data. Among them, compounds 1, 3 and 5 were unambiguously established by Cu-Kα X-ray crystallographic analysis. Furthermore, compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC value of 2.11 ± 0.35 μM. And the leakage of LDH from glutamate-induced PC-12 was significantly reduced by compound 1 at concentration of 10 μM.
从 Vladimiria souliei 中分离得到了两种罕见的 C 倍半萜二聚体，vlasouliolides J-K（1-2），以及三种 C 倍半萜二聚体，vlasoulioliones A-C（3-5）。通过 NMR 和 MS 光谱数据阐明了它们的化学结构。其中，通过 Cu-Kα X 射线晶体学分析明确确定了化合物 1、3 和 5 的结构。此外，化合物 1 对谷氨酸诱导的 PC-12 细胞神经毒性表现出显著的神经保护作用，EC 值为 2.11±0.35μM。并且，化合物 1 在 10μM 浓度下可显著减少谷氨酸诱导的 PC-12 中 LDH 的漏出。
Zotero 插件