Department of General Surgery, The First People's Hospital of Neijiang, Neijiang, 641000, Sichuan Province, PR China.
Int J Surg. 2018 Jul;55:39-45. doi: 10.1016/j.ijsu.2018.05.018. Epub 2018 May 18.
Controlling nutritional status (CONUT) score has been reported to correlate with gastrointestinal (GI) cancer prognosis, but the results remain inconsistent. This study was to synthetically determine the associations between CONUT score and prognosis in GI cancers.
Online databases PubMed, Web of Science, Cochrane library, Embase, Google scholar, Wanfang and National Knowledge Infrastructure (CNKI) were searched for eligible articles published prior to March 10, 2018. Pooled Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were used to assess the prognostic potential of CONUT score in patients with GI cancers using Stata SE 12.0.
A total of 9 articles comprising 2400 patients were included in the analysis. Overall, CONUT score greater than the cutoff predicted poor 5-year overall survival for patients with GI cancers (HR = 2.39, 95% CI: 1.84-2.95, p < 0.001) and 5-year cancer-specific survival (HR: 3.47, 95% CI: 1.75-5.19, p < 0.001). And patients with high CONUT score were at significantly greater risk of relapse/recurrence (HR = 1.64, 95% CI: 1.30-1.98, p < 0.001).
CONUT could be a noninvasive prognostic indicator that useful for predicting long-term survival in GI cancer patients after surgery.
控制营养状况（CONUT）评分与胃肠道（GI）癌症的预后相关，但结果仍不一致。本研究旨在综合评估 CONUT 评分与 GI 癌症患者预后之间的关系。
检索 PubMed、Web of Science、Cochrane 图书馆、Embase、Google 学术、万方和中国知网（CNKI）等在线数据库，查找截至 2018 年 3 月 10 日前发表的关于 CONUT 评分与 GI 癌症患者预后相关性的研究。采用 Stata SE 12.0 软件进行荟萃分析，采用合并危险比（HR）及其 95%置信区间（95%CI）来评估 CONUT 评分对 GI 癌症患者预后的预测价值。
共纳入 9 项研究，包含 2400 例患者。总体而言，CONUT 评分大于临界值提示 GI 癌症患者 5 年总生存率（HR=2.39，95%CI：1.84-2.95，p<0.001）和 5 年癌症特异性生存率（HR：3.47，95%CI：1.75-5.19，p<0.001）较差。高 CONUT 评分的患者复发/转移风险显著增加（HR=1.64，95%CI：1.30-1.98，p<0.001）。
CONUT 是一种非侵入性的预后指标，可用于预测 GI 癌症患者手术后的长期生存。
