Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Gene. 2018 Aug 20;668:155-165. doi: 10.1016/j.gene.2018.05.062. Epub 2018 May 18.
With the development of GWAS, both TNFAIP3 and TNIP1 were revealed to be susceptibility genes of SLE. However, some other studies revealed no association between TNFAIP3, TNIP1 and SLE susceptibility. In order to estimate such association more precisely and systemically, a meta-analysis was conducted.
Studies on the association between TNFAIP3 rs2230926, TNIP1 rs7708392 and SLE risk were carefully selected via searching 3 databases (Pubmed, Embase, and Web of Science). A fixed- or random-effect model was used according to the heterogeneity, and a subgroup analysis by ethnicity was also performed.
26 studies from 18 articles involving a total of 21,372 patients and 30,165 controls were analyzed for TNFAIP3 rs2230926. A significant association between the minor G allele of TNFAIP3 rs2230926 and SLE risk was found via a random-effect model (OR = 1.643, 95% CI = (1.462, 1.847), p < 0.01). In the subgroup analysis by ethnicity, significant correlations were also found in all Caucasians, Asians, and Africans (OR = 1.675, 95% CI = (1.353, 2.074), p < 0.01; OR = 1.738, 95% CI = (1.557, 1.940), p < 0.01; OR = 1.324, 95% CI = (1.029, 1.704), p < 0.05). As for TNIP1 rs7708392, 21 studies from 12 articles involving 24,716 cases and 32,200 controls were analyzed. A significant association of the minor C allele of TNIP1 rs7708392 and SLE risk was found via a random-effect model (OR = 1.247, 95% CI = (1.175, 1.323), p < 0.01). In the subgroup analysis by ethnicity, significant correlations were found in Caucasians, and Africans (OR = 1.317, 95% CI = (1.239, 1.401), p < 0.01; OR = 1.210, 95% CI = (1.108, 1.322), p < 0.01). However, there was no significant association in Asians (OR = 1.122, 95% CI = (0.953, 1.321), p > 0.05).
The minor G allele of TNFAIP3 rs2230926 was associated with increased risk of SLE in all Caucasians, Asians, and Africans. The minor C allele of TNIP1 rs7708392 was associated with the increased risk of SLE in Caucasians and Africans, while it was not associated with SLE susceptibility in Asians.
随着 GWAS 的发展，TNFAIP3 和 TNIP1 均被揭示为 SLE 的易感基因。然而，其他一些研究并未发现 TNFAIP3、TNIP1 与 SLE 易感性之间存在关联。为了更准确和系统地评估这种关联，进行了荟萃分析。
通过搜索 3 个数据库（Pubmed、Embase 和 Web of Science），仔细选择了关于 TNFAIP3 rs2230926、TNIP1 rs7708392 与 SLE 风险关联的研究。根据异质性，使用固定效应或随机效应模型，并且还进行了按种族亚组分析。
对 18 篇文章中的 26 项研究进行了分析，共纳入 21372 名患者和 30165 名对照。通过随机效应模型发现，TNFAIP3 rs2230926 的次要 G 等位基因与 SLE 风险之间存在显著关联（OR=1.643，95%CI=（1.462,1.847），p<0.01）。在按种族进行的亚组分析中，在所有高加索人、亚洲人和非洲人中也发现了显著相关性（OR=1.675，95%CI=（1.353,2.074），p<0.01；OR=1.738，95%CI=（1.557,1.940），p<0.01；OR=1.324，95%CI=（1.029,1.704），p<0.05）。对于 TNIP1 rs7708392，对 12 篇文章中的 21 项研究进行了分析，共纳入 24716 例病例和 32200 例对照。通过随机效应模型发现，TNIP1 rs7708392 的次要 C 等位基因与 SLE 风险之间存在显著关联（OR=1.247，95%CI=（1.175,1.323），p<0.01）。在按种族进行的亚组分析中，在高加索人和非洲人中发现了显著相关性（OR=1.317，95%CI=（1.239,1.401），p<0.01；OR=1.210，95%CI=（1.108,1.322），p<0.01）。然而，在亚洲人中没有显著相关性（OR=1.122，95%CI=（0.953,1.321），p>0.05）。
TNFAIP3 rs2230926 的次要 G 等位基因与所有高加索人、亚洲人和非洲人中的 SLE 风险增加相关。TNIP1 rs7708392 的次要 C 等位基因与高加索人和非洲人中的 SLE 风险增加相关，而与亚洲人中的 SLE 易感性无关。
