Greek Ray, Menache Andre, Rice Mark J
Americans For Medical Advancement, 2251 Refugio Rd, Goleta, CA 93117, USA.
Department of Anesthesiology, University of Florida College of Medicine, PO Box 100254, Gainesville, FL 32610-0254, USA.
Per Med. 2012 Jan;9(1):47-64. doi: 10.2217/pme.11.89.
Personalized medicine is based on intraspecies differences. It is axiomatic that small differences in genetic make-up can result in dramatic differences in response to drugs or disease. To express this in more general terms: in any given complex system, small changes in initial conditions can result in dramatically different outcomes. Despite human variability and intraspecies variation in other species, nonhuman species are still the primary model for ascertaining data for humans. We call this practice into question and conclude that human-based research should be the primary means for obtaining data about human diseases and responses to drugs.
个性化医疗基于种内差异。基因组成上的微小差异会导致对药物或疾病的反应产生巨大差异，这是不言而喻的。用更通俗的话来讲：在任何给定的复杂系统中，初始条件的微小变化都可能导致截然不同的结果。尽管人类存在变异性，其他物种也存在种内变异，但非人类物种仍是确定人类数据的主要模型。我们对这种做法提出质疑，并得出结论，基于人类的研究应该是获取有关人类疾病和药物反应数据的主要手段。
