肿瘤的免疫监视和热休克蛋白-CD91 途径。
Immunosurveillance of cancer and the heat shock protein-CD91 pathway.
机构信息
Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
出版信息
Cell Immunol. 2019 Sep;343:103814. doi: 10.1016/j.cellimm.2018.05.007. Epub 2018 May 16.
Abstract
The intracellular functions of heat shock proteins (HSPs) as chaperones of macromolecules are well known. Current observations point to a role of these chaperones in initiating and modulating immune responses to tumors via receptor(s) on dendritic cells. In this article we provide an insight into, and a basis for, the importance of these HSP-mediated immune responses in rejecting nascent and emerging tumors.
摘要
热休克蛋白（HSPs）作为大分子伴侣的细胞内功能是众所周知的。目前的观察结果表明，这些伴侣蛋白通过树突状细胞上的受体在启动和调节对肿瘤的免疫反应方面发挥作用。在本文中，我们深入探讨了 HSP 介导的免疫反应在排斥新出现和新兴肿瘤中的重要性，并为其提供了依据。
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