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肿瘤的免疫监视和热休克蛋白-CD91 途径。

Immunosurveillance of cancer and the heat shock protein-CD91 pathway.

机构信息

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, United States.

出版信息

Cell Immunol. 2019 Sep;343:103814. doi: 10.1016/j.cellimm.2018.05.007. Epub 2018 May 16.

DOI:10.1016/j.cellimm.2018.05.007
PMID:29784128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6239979/
Abstract

The intracellular functions of heat shock proteins (HSPs) as chaperones of macromolecules are well known. Current observations point to a role of these chaperones in initiating and modulating immune responses to tumors via receptor(s) on dendritic cells. In this article we provide an insight into, and a basis for, the importance of these HSP-mediated immune responses in rejecting nascent and emerging tumors.

摘要

热休克蛋白（HSPs）作为大分子伴侣的细胞内功能是众所周知的。目前的观察结果表明，这些伴侣蛋白通过树突状细胞上的受体在启动和调节对肿瘤的免疫反应方面发挥作用。在本文中，我们深入探讨了 HSP 介导的免疫反应在排斥新出现和新兴肿瘤中的重要性，并为其提供了依据。

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本文引用的文献

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HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells.热休克蛋白通过抗原呈递细胞中的 DNA 甲基组重塑来驱动二态 T 细胞免疫应答。
Nat Commun. 2017 May 31;8:15648. doi: 10.1038/ncomms15648.
2
Phenotypically distinct helper NK cells are required for gp96-mediated anti-tumor immunity.表型不同的辅助 NK 细胞是 gp96 介导的抗肿瘤免疫所必需的。
Sci Rep. 2016 Jul 19;6:29889. doi: 10.1038/srep29889.
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Molecular chaperones: guardians of the proteome in normal and disease states.分子伴侣：正常及疾病状态下蛋白质组的守护者
源自肿瘤内部的定向火力：基于信使核糖核酸的疫苗瘤内给药以动员记忆性免疫并引导针对病原体的免疫反应靶向实体瘤。
Cell Discov. 2025 Jan 2;10(1):127. doi: 10.1038/s41421-024-00743-3.
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The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease.热休克蛋白在炎症性肠病发展中的多重作用
Curr Mol Med. 2025;25(2):132-145. doi: 10.2174/0115665240286793240306053111.
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The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I-Associated Peptides.从基因组角度看免疫肽组学：建立 MHC I 相关肽的非经典景观。
Cancer Immunol Res. 2023 Jun 2;11(6):747-762. doi: 10.1158/2326-6066.CIR-22-0621.
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Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach.免疫细胞和受体在癌症治疗中的作用：一种免疫治疗方法。
Vaccines (Basel). 2022 Sep 7;10(9):1493. doi: 10.3390/vaccines10091493.
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