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糖组学:在数据的海洋中架起沟通的桥梁。

Glycoinformatics: Bridging Isolated Islands in the Sea of Data.

机构信息

Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, 119991, Russia.

出版信息

Angew Chem Int Ed Engl. 2018 Nov 12;57(46):14986-14990. doi: 10.1002/anie.201803576. Epub 2018 Oct 11.

Abstract

Glycoinformatics is an actively developing scientific discipline, which provides scientists with the means of access to the data on natural glycans and with various tools of their processing. However, the informatization of glycomics has a long way to go before catching up with genomics and proteomics. In this Viewpoint, we review the current situation in glycoinformatics and discuss its achievements and shortcomings, emphasizing the major drawbacks: the lack of recognized standards, protocols, data indices and tools, and the informational isolation of the existing projects. We reiterate possible solutions of the persistent issues and describe our vision of an ideal glycoinformatics project.

摘要

糖组学是一门快速发展的科学领域,它为科学家提供了获取天然糖链数据的手段和对其进行处理的各种工具。然而,糖组学的信息化还有很长的路要走,才能赶上基因组学和蛋白质组学。在本观点中,我们回顾了糖组学的现状,讨论了它的成就和缺点,强调了主要的缺点:缺乏公认的标准、协议、数据索引和工具,以及现有项目的信息隔离。我们重申了可能的解决方案,并描述了我们对理想糖组学项目的看法。

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