Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati 45267, OH, USA.
Department of Epidemiology, Brown University School of Public Health, 121 South Main St, Box G-S121-2, Providence 02912, RI, USA.
Environ Int. 2018 Aug;117:339-347. doi: 10.1016/j.envint.2018.05.019. Epub 2018 May 19.
Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood.
We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years.
Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ∑PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI -40.8%, -11.3%) in TSH. A ten-fold increase in prenatal ∑PBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T (FT) in males. Prenatal ∑PBDEs were not associated with TT, FT, or total T.
These findings suggest an inverse relationship between prenatal ∑PBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.
多溴二苯醚（PBDEs）会降低动物研究中的血清甲状腺激素浓度，但很少有研究探讨早期 PBDE 暴露对儿童期甲状腺激素紊乱的影响。
我们使用了来自健康结果和环境测量研究（2003-2006 年，俄亥俄州辛辛那提）中的 162 对母婴数据。我们在孕妇妊娠 16±3 周时测量母体血清中的 PBDEs，在儿童 1-3 岁时测量其血清中的 PBDEs。我们在 3 岁时测量血清中的甲状腺激素。我们使用多信息源模型来研究产前和早期 PBDE 暴露与 3 岁时甲状腺激素水平之间的关系。
产前 PBDEs 与 3 岁时促甲状腺激素（TSH）水平降低有关。产前∑PBDEs（BDE-28、-47、-99、-100 和-153）增加 10 倍与 TSH 降低 27.6%（95%CI-40.8%，-11.3%）有关。产前∑PBDEs 增加 10 倍与游离三碘甲状腺原氨酸（FT）增加 0.25pg/mL（0.07，0.43）有关。儿童性别修饰了产前 PBDEs 与甲状腺激素之间的关系，在女性中 TSH 显著降低，而在男性中游离 T（FT）降低。产前∑PBDEs 与 TT、FT 或总 T 无关。
这些发现表明，产前∑PBDEs 与 3 岁时的 TSH 呈负相关。这些关联可能存在性别差异，女性中 BDE-47 和-99 与 TSH 呈负相关，而男性中则不存在关联。
