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120例儿童继发孔型房间隔缺损手术闭合后的近期经验及随访

Recent Experience and Follow-Up After Surgical Closure of Secundum Atrial Septal Defect in 120 Children.

作者信息

de Beco Geoffroy, Mambour Natasha, Vô Christophe, Vanhoutte Laetitia, Moniotte Stéphane, Poncelet Alain, Sluysmans Thierry

机构信息

Department of Cardiac Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Cardiologie Pédiatrique et Congénitale, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium.

出版信息

Pediatr Cardiol. 2018 Oct;39(7):1440-1444. doi: 10.1007/s00246-018-1914-8. Epub 2018 May 22.

Abstract

While percutaneous catheter closure proves an effective treatment for secundum atrial septal defect (ASD2), some child patients require surgical closure. We assessed the risks associated with isolated surgical ASD2 closure by reviewing the outcomes of 120 children operated on between 1999 and 2011 (mean age 4.6 ± 3.9 years, mean weight 17 ± 12 kg). Direct sutures were performed in 4% and patch closures in 96%. The mean cardiopulmonary bypass duration was 38 ± 14 min, aortic cross-clamp time 19 ± 9 min, intensive care unit length of stay 1.6 ± 1.1 days, hospital stay 11.2 ± 5.1 days. There were no complications in 60 patients (50%) and major complications in 8 (6.7%), with 1 patient (0.8%) dying of pneumonia-induced sepsis, 2 (1.7%) requiring revision surgery, 3 (2.5%) requiring invasive treatment (2 pericardial drainage, 1 successful resuscitation), and 2 (1.7%) presenting thromboembolisms (1 cerebral stroke, 1 cardiac thrombus). In hospital minor complications occurred in 22 patients: 17 pericardial effusions (15%), 15 infections requiring treatment (12.5%), 1 sternal instability (0.8%), 4 anemias requiring transfusion (3.3%), 7 pulmonary atelectasis (6%), and 2 post-extubation glottis edema (1.7%). At early outpatient follow-up, complications occurred in 21 patients: 16 (13.3%) pericardial effusions, 4 (3.3%) infections requiring treatment, and 3 (2.5%) keloid scarring. No complications occurred during long-term follow-up. In line with published data, mortality was low (0.8%), yet major complications (6.7%) were more common in these cases than those following percutaneous ASD2 closure. Minor complications were frequent (43%) with no long-term sequelae.

摘要

虽然经皮导管封堵术被证明是治疗继发孔型房间隔缺损(ASD2)的有效方法,但一些儿童患者仍需要手术封堵。我们通过回顾1999年至2011年间接受手术的120名儿童(平均年龄4.6±3.9岁,平均体重17±12千克)的手术结果,评估了单纯手术封堵ASD2的相关风险。4%的患者采用直接缝合,96%的患者采用补片修补。平均体外循环时间为38±14分钟,主动脉阻断时间为19±9分钟,重症监护病房住院时间为1.6±1.1天,住院时间为11.2±5.1天。60例患者(50%)无并发症,8例(6.7%)发生主要并发症,其中1例患者(0.8%)死于肺炎诱发的败血症,2例(1.7%)需要再次手术,3例(2.5%)需要侵入性治疗(2例心包引流,1例成功复苏),2例(1.7%)出现血栓栓塞(1例脑卒,1例心脏血栓)。22例患者在住院期间发生轻微并发症:17例心包积液(15%),15例需要治疗的感染(12.5%),1例胸骨不稳定(0.8%),4例需要输血的贫血(3.3%),7例肺不张(6%),2例拔管后声门水肿(1.7%)。在早期门诊随访中,21例患者出现并发症:16例(13.3%)心包积液,4例(3.3%)需要治疗的感染,3例(2.5%)瘢痕疙瘩。长期随访期间未发生并发症。与已发表的数据一致,死亡率较低(0.8%),但这些病例中的主要并发症(6.7%)比经皮ASD2封堵术后的更常见。轻微并发症很常见(43%),且无长期后遗症。

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