Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
SHARE INDIA - MediCiti Institute of Medical Sciences, Ghanpur Village, Medchal District, Telangana, India.
Arch Osteoporos. 2018 May 22;13(1):60. doi: 10.1007/s11657-018-0473-1.
Peripheral quantitative computed tomography (pQCT) provides biomechanical estimates of bone strength. Rural South Indian men have reduced biomechanical indices of bone strength compared to US Caucasian and Afro-Caribbean men. This suggests an underlying higher risk of osteoporotic fractures and greater future fracture burden among the rural South Indian men.
Geographical and racial comparisons of bone mineral density (BMD) have largely focused on DXA measures of areal BMD. In contrast, peripheral quantitative computed tomography (pQCT) measures volumetric BMD (vBMD), bone structural geometry and provides estimates of biomechanical strength. To further understand potential geographical and racial differences in skeletal health, we compared pQCT measures among US Caucasian, Afro-Caribbean, and rural South Indian men.
We studied men aged ≥ 60 years enrolled in the Mobility and Independent Living among Elders Study (MILES) in rural south India (N = 245), Osteoporotic Fractures in Men Study (MrOS) in the US (N = 1148), and the Tobago Bone Health Study (N = 828).
The BMI (kg/m) of rural South Indian men (21.6) was significantly lower compared to the US Caucasians (28) and Afro-Caribbean men (26.9). Adjusting for age, height, body weight, and grip strength; rural South Indian men compared to US Caucasians had significantly lower trabecular vBMD [- 1.3 to - 1.5 standard deviation (SD)], cortical thickness [- 0.8 to - 1.2 SD]; significantly higher endosteal circumference [0.5 to 0.8 SD]; but similar cortical vBMD. Afro-Caribbean men compared to US Caucasians had similar trabecular vBMD but significantly higher cortical vBMD [0.9 to 1.2 SD], SSIp [0.2 to 1.4 SD], and tibial endosteal circumference [1 SD], CONCLUSIONS: In comparison to US Caucasians, rural South Indian men have reduced bone strength (lower trabecular vBMD) and Afro-Caribbean men have greater bone strength (higher cortical vBMD). These results suggest an underlying higher risk of osteoporotic fractures and greater future fracture burden among rural South Indian men.
外周定量计算机断层扫描（pQCT）提供了骨骼强度的生物力学估计。与美国白人和非裔加勒比海人相比，印度南部农村男性的骨骼强度的生物力学指标较低。这表明农村印度南部男性发生骨质疏松性骨折的风险更高，未来骨折负担更重。
骨密度（BMD）的地理和种族比较主要集中在 DXA 测量的面积 BMD 上。相比之下，外周定量计算机断层扫描（pQCT）测量体积 BMD（vBMD）、骨骼结构几何形状，并提供生物力学强度的估计。为了进一步了解骨骼健康方面的潜在地理和种族差异，我们比较了美国白种人、非裔加勒比人和印度南部农村男性的 pQCT 测量值。
我们研究了年龄≥60 岁的男性，他们参加了印度南部农村的移动和独立生活研究（MILES）（n=245）、美国男性骨质疏松性骨折研究（MrOS）（n=1148）和多巴哥骨骼健康研究（n=828）。
与美国白人和非裔加勒比男性相比，印度南部农村男性的 BMI（kg/m）明显较低（21.6 对 28 和 26.9）。在调整年龄、身高、体重和握力后；与美国白种人相比，印度南部农村男性的骨小梁 vBMD 明显较低（-1.3 至-1.5 标准差（SD））、皮质厚度明显较低（-0.8 至-1.2 SD）；而内骨皮质周长较高（0.5 至 0.8 SD）；但皮质 vBMD 相似。与美国白种人相比，非裔加勒比男性的骨小梁 vBMD 相似，但皮质 vBMD 明显较高（0.9 至 1.2 SD）、SSIp（0.2 至 1.4 SD）和胫骨内骨皮质周长较高（1 SD）。
与美国白种人相比，印度南部农村男性的骨骼强度较低（较低的骨小梁 vBMD），而非裔加勒比男性的骨骼强度较高（较高的皮质 vBMD）。这些结果表明，农村印度南部男性发生骨质疏松性骨折的风险更高，未来骨折负担更重。
