Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Microbial Evolutionary Genomics, Institut Pasteur, 25-28 rue du Docteur Roux, 75015, Paris, France.
Nucleic Acids Res. 2018 Jul 2;46(W1):W246-W251. doi: 10.1093/nar/gky425.
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous mobile genetic elements, such as phages or plasmids. CRISPRCasFinder allows the identification of both CRISPR arrays and Cas proteins. The program includes: (i) an improved CRISPR array detection tool facilitating expert validation based on a rating system, (ii) prediction of CRISPR orientation and (iii) a Cas protein detection and typing tool updated to match the latest classification scheme of these systems. CRISPRCasFinder can either be used online or as a standalone tool compatible with Linux operating system. All third-party software packages employed by the program are freely available. CRISPRCasFinder is available at https://crisprcas.i2bc.paris-saclay.fr.
CRISPR（成簇规律间隔短回文重复）序列及其相关（Cas）蛋白赋予细菌和古菌针对外来可移动遗传元件（如噬菌体或质粒）的适应性免疫。CRISPRCasFinder 可识别 CRISPR 序列和 Cas 蛋白。该程序包括：（i）改进的 CRISPR 序列检测工具，可基于评分系统方便专家验证，（ii）CRISPR 方向预测，以及（iii）Cas 蛋白检测和分型工具，该工具已更新以匹配这些系统的最新分类方案。CRISPRCasFinder 可在线使用，也可作为与 Linux 操作系统兼容的独立工具使用。该程序使用的所有第三方软件包均可免费获得。CRISPRCasFinder 可在 https://crisprcas.i2bc.paris-saclay.fr 获取。
