Universidade Tiradentes - Aracaju (SE), Brazil.
Rev Bras Epidemiol. 2023 Sep 18;26:e230041. doi: 10.1590/1980-549720230041. eCollection 2023.
The objectives of this study were: (1) to analyze the temporal trend of tuberculosis treatment outcomes in the state of Sergipe; (2) to identify the existence of seasonality of tuberculosis; (3) to verify the influence of the rapid molecular test (MTB-RIF) in the time series of tuberculosis and its treatment outcomes in the state of Sergipe; and (4) to verify treatment outcomes.
Ecological study on tuberculosis and three treatment outcomes (cure, interruption of treatment, and death) extracted from Datasus. Incidence and mortality rates were calculated for the crude occurrences of cases and deaths and the proportions of cure and interruption of treatment (%). The time series was analyzed using Prais-Winsten regression from Jan to Dec/2021.
The total incidence rate was 36.35 cases per 100,000 inhabitants, with an increase of 0.44% per month (95%CI 0.35; 0.54). The cure rate was 64.0% with a steady trend (p>0.05). The percentage of treatment interruption was 13.3%, with a reduction of -0.73%/month (95%CI -1.11; -0.34). The total mortality rate was 1.92 deaths/100,000 inhabitants with a stationary trend. After the implementation of the MTB-RIF, there was an increase in the incidence rate of 0.65% per month. Seasonality was not identified in any of the analyses performed (p>0.05).
There was an increase in incidence rates, reduction in treatment interruption and mortality in the state of Sergipe. Seasonality was not identified. The rapid molecular test showed a growth effect on the incidence rate.
本研究的目的是：（1）分析塞尔希培州结核病治疗结果的时间趋势；（2）确定结核病是否存在季节性；（3）验证快速分子检测（MTB-RIF）在结核病及其在塞尔希培州治疗结果的时间序列中的影响；（4）验证治疗结果。
对结核病和从 Datasus 提取的三种治疗结果（治愈、治疗中断和死亡）进行生态学研究。对病例和死亡的粗发生率以及治愈率和治疗中断率（%）计算发病率和死亡率。使用普赖斯-温斯坦回归从 2021 年 1 月至 12 月分析时间序列。
总发病率为每 100,000 居民 36.35 例，每月增长 0.44%（95%CI 0.35；0.54）。治愈率为 64.0%，呈稳定趋势（p>0.05）。治疗中断率为 13.3%，每月减少-0.73%（95%CI -1.11；-0.34）。总死亡率为每 100,000 居民 1.92 人，呈稳定趋势。MTB-RIF 实施后，发病率每月增加 0.65%。在进行的任何分析中均未发现季节性（p>0.05）。
塞尔希培州的发病率上升，治疗中断和死亡率下降。未发现季节性。快速分子检测显示对发病率有增长作用。
