朝着个体化肾小球表型研究迈进：肾脏活检精准医学的到来。
Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies.
机构信息
Center for Renal Precision Medicine, Division of Nephrology, Department of Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA.
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA.
出版信息
Kidney Int. 2018 Jun;93(6):1265-1267. doi: 10.1016/j.kint.2018.01.035.
Abstract
The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase-enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.
摘要
肾脏病学精准医学的道路正在迅速接近。在本卷中，作者在小鼠和人肾脏的单个肾小球水平上对肾小球蛋白质组进行了描述。作者使用单管固相增强样品制备（SP3）方法证明，LAMP1 是一种关键的溶酶体蛋白，在肾小球疾病中增加，可能发挥致病作用。
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