肾皮质氧合的异质性：眼见为实。
Heterogeneity of renal cortical oxygenation: seeing is believing.
机构信息
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia.
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia.
出版信息
Kidney Int. 2018 Jun;93(6):1278-1280. doi: 10.1016/j.kint.2018.01.039.
The limited spatial and temporal resolution of available methods for quantifying renal tissue oxygen tension is a major impediment to identification of the roles of renal hypoxia in kidney diseases. Intravital phosphorescence lifetime imaging microscopy allows cellular oxygen tension in the renal cortex of live animals to be resolved to the level of individual tubular cross-sections. This paves the way for future investigations of the spatial relationships between cellular hypoxia and pathophysiological events in kidney disease.
现有的定量检测肾组织氧张力的方法在空间和时间分辨率上均存在一定的局限性，这极大地阻碍了人们对肾脏缺氧在肾脏疾病中的作用的认识。活体磷光寿命显微镜可对活体动物的肾皮质中细胞氧张力进行分辨，达到单个肾小管横截面积的水平。这为今后研究肾脏疾病中细胞缺氧与病理生理事件之间的空间关系奠定了基础。
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