可逆转（病理）生理相关测试干预：原理与实例。
Reversible (Patho)Physiologically Relevant Test Interventions: Rationale and Examples.
机构信息
Working Group Integrative Kidney Physiology, Institute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.
Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Free University Berlin, Berlin, Germany.
出版信息
Methods Mol Biol. 2021;2216:57-73. doi: 10.1007/978-1-0716-0978-1_4.
Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe test interventions that are used to study the control of renal hemodynamics and oxygenation in experimental animals in the context of kidney-specific control of hemodynamics and oxygenation. The rationale behind the use of the individual tests, the physiological responses of renal hemodynamics and oxygenation, the use in preclinical studies, and the possible application in humans are discussed.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
肾脏组织低灌注和缺氧是各种来源的急性肾损伤病理生理学的早期关键因素，也可能促进急性损伤向慢性肾脏病的进展。在这里，我们描述了一些测试干预措施，这些措施用于在肾脏特异性控制肾血流动力学和氧合的背景下，研究实验动物的肾血流动力学和氧合的控制。讨论了使用这些测试的原理、肾血流动力学和氧合的生理反应、在临床前研究中的应用以及在人类中的可能应用。这一章基于 COST 行动 PARENCHIMA 的工作，该行动是一个由欧洲科学技术合作组织（COST）计划资助的、由社区驱动的网络，旨在提高肾脏 MRI 生物标志物的可重复性和标准化。
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