Li Xiao-Hua, Han Xue-Hua, Qin Ling-Ling, He Jun-Lin, Cao Zhi-Xing, Gu Yu-Cheng, Guo Da-Le, Deng Yun
a The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources , Chengdu University of Traditional Chinese Medicine , Chengdu , P R China.
b Syngenta Jealott's Hill International Research Centre , Berkshire , UK.
Nat Prod Res. 2019 Jul;33(13):1870-1875. doi: 10.1080/14786419.2018.1478824. Epub 2018 May 24.
Four previously undescribed isochromanes were isolated from the fermentation broth of an endophytic fungus , which was obtained from the fruiting body of . Their structures were elucidated through extensive spectroscopic analyses. One racemic isochromane was further purified by chiral HPLC to yield a pair of enantiomers and their absolute configurations were determined by quantum chemical ECD calculations. These isolated compounds were evaluated for cytotoxicity against two cell lines (MV4-11 and MDA-ME-231) and the result showed that compounds and exhibited moderate growth inhibition against MV4-11 cell line.
从一种内生真菌的发酵液中分离出四种先前未描述的异色满，该内生真菌是从……的子实体中获得的。通过广泛的光谱分析阐明了它们的结构。一种外消旋异色满通过手性高效液相色谱进一步纯化，得到一对对映体，并通过量子化学电子圆二色光谱计算确定了它们的绝对构型。评估了这些分离出的化合物对两种细胞系（MV4-11和MDA-ME-231）的细胞毒性，结果表明化合物……和……对MV4-11细胞系表现出中等程度的生长抑制作用。
