从滇石梓茎中分离出的内生真菌烟曲霉产生的代谢产物
Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv.
作者信息
Shi Yu-Sheng, Zhang Yan, Chen Xiao-Zhong, Zhang Ning, Liu Yun-Bao
机构信息
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Molecules. 2015 Jun 11;20(6):10793-9. doi: 10.3390/molecules200610793.
A new diketopiperazine alkaloid named spirotryprostatin K (1), and five known alkaloids, spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H),2'-[2H]-indole]-3',5,10(1'H) trione (2), 6-methoxyspirotryprostatin B (3), pseurotin A (4), N-β-acetyltryptamine (5), and lumichrome (6) were isolated from the endophytic fungus Aspergillus fumigatus. The structure and the absolute configuration of spirotryprostatin K were established by extensive spectroscopic analyses, acid hydrolysis and ECD calculations. Pseurotin A exhibited indirect anti-inflammatory activity by suppressing the lipopolysaccharide-induced proinflammatory factors in BV2 microglial cells, with an IC50 of 5.20 µM.
从烟曲霉内生真菌中分离出一种名为螺旋色肽素K（1）的新型二酮哌嗪生物碱以及五种已知生物碱，即螺[5H,10H - 二吡咯并[1,2 - a:1',2'-d]吡嗪 - 2(3H),2'-[2H]-吲哚]-3',5,10(1'H)三酮（2）、6 - 甲氧基螺旋色肽素B（3）、假丝菌素A（4）、N - β - 乙酰色胺（5）和光色素（6）。通过广泛的光谱分析、酸水解和ECD计算确定了螺旋色肽素K的结构和绝对构型。假丝菌素A通过抑制BV2小胶质细胞中脂多糖诱导的促炎因子表现出间接抗炎活性，IC50为5.20 μM。
Zotero 插件