Klinkenberg-Knol E C, Festen H P, Meuwissen S G
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
Aliment Pharmacol Ther. 1988 Jun;2(3):221-7. doi: 10.1111/j.1365-2036.1988.tb00691.x.
Ambulatory 24-h pH monitoring in the distal oesophagus was performed in seven patients with erosive or ulcerative reflux oesophagitis to compare the effects of omeprazole and ranitidine in the management of gastro-oesophageal reflux disease. In a double-blind, crossover study patients were treated with either 60 mg o.m. omeprazole or 150 mg b.d. ranitidine. The pH measurements were performed before treatment and on the fourteenth day of treatment with either regimen. The total acid exposure time (percentage total time pH less than 4) was abnormal in six out of seven patients before treatment. During treatment with omeprazole the acid exposure time of five patients was normal in comparison with only two patients during ranitidine therapy. However, even with a rather high dose of omeprazole, pathological gastro-oesophageal reflux may still occur.
对7例糜烂性或溃疡性反流性食管炎患者进行了食管远端24小时动态pH监测，以比较奥美拉唑和雷尼替丁在治疗胃食管反流病中的效果。在一项双盲交叉研究中，患者分别接受每日一次60mg奥美拉唑或每日两次150mg雷尼替丁治疗。在治疗前以及使用任一治疗方案的第14天进行pH测量。治疗前7例患者中有6例的总酸暴露时间（pH值小于4的总时间百分比）异常。在使用奥美拉唑治疗期间，5例患者的酸暴露时间恢复正常，而使用雷尼替丁治疗期间只有2例恢复正常。然而，即使使用相当高剂量的奥美拉唑，病理性胃食管反流仍可能发生。
