Hawkey C J, Somerville K W, Marshall S
Department of Therapeutics, University Hospital, Nottingham, UK.
Aliment Pharmacol Ther. 1988 Jun;2(3):245-52. doi: 10.1111/j.1365-2036.1988.tb00694.x.
The ability of ranitidine to protect the human gastric mucosa against aspirin-induced damage was investigated by timed measurements of blood loss collected by gastric washing. Ranitidine (150 mg) 1 h or 5 h before 900 mg aspirin (5 doses of each) over 48 h reduced subsequent mean bleeding from 7.7 microliters/10 min to 2.6 microliters/10 min or 3.4 microliters/10 min, respectively. Both regimens were antisecretory at the time of aspirin administration, as judged by a rise in the pH of the aspirated washings. The prolonged protection against aspirin-induced bleeding achieved with twice daily dosing with ranitidine has clinical potential in the management of patients taking anti-inflammatory drugs.
通过定时测量洗胃收集的失血量，研究了雷尼替丁保护人胃黏膜免受阿司匹林诱导损伤的能力。在48小时内服用900毫克阿司匹林（各5剂）前1小时或5小时给予雷尼替丁（150毫克），随后平均出血量分别从7.7微升/10分钟降至2.6微升/10分钟或3.4微升/10分钟。根据吸出冲洗液pH值的升高判断，两种给药方案在服用阿司匹林时均具有抗分泌作用。雷尼替丁每日两次给药对阿司匹林诱导的出血具有延长的保护作用，这在服用抗炎药物患者的管理中具有临床潜力。
