Hawkey C J, Prichard P J, Somerville K W
Scand J Gastroenterol Suppl. 1986;125:170-3. doi: 10.3109/00365528609093834.
Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.
前列腺素可保护动物的胃黏膜，但关于其在人体中存在独立于pH值变化的效应的证据并不充分。非甾体抗炎药所致的胃肠道出血是一个主要的临床问题，我们在一个测量短期服用阿司匹林引起的出血率的模型系统中对此进行了研究。在测试的各种策略中，只有那些能提高胃内pH值的策略可减少阿司匹林引起的出血。
