a School of Materials Science and Engineering , Southwest University of Science and Technology , Mianyang , P. R. China.
J Biomater Sci Polym Ed. 2018 Sep;29(13):1643-1655. doi: 10.1080/09205063.2018.1481005. Epub 2018 Jun 4.
A series of injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels (HA/CMC) was prepared via disulfide bonds by the oxidation of dissolved oxygen. The results showed that HA/CMC hydrogels exhibited tunable gelling time, appropriate rheology properties, high swelling ratio, good stability, and sustained drug release ability. The gelling time of HA/CMC hydrogels ranged from 1.4 to 7.0 min, and the values of the storage modulus, complex shear modulus, dynamic viscosity, and yield stress of HA3/CMC3 hydrogel were about 5869 Pa, 5870 Pa, 587 Pa·s, and 1969 Pa, respectively. The degradation percentage of HA1/CMC1, HA2/CMC2, and HA3/CMC3 hydrogels were about 60, 49, and 41% after incubating 42 days, and the in vitro cumulative release percentage of BSA from HA1/CMC1, HA2/CMC2, and HA3/CMC3 drug-loaded hydrogels were about 99, 91, and 82% after 30 days. The series of injectable in situ cross-linking HA/CMC hydrogels exhibited good comprehensive performance, signifying that these hydrogels could be potentially used in the fields of short- and medium-term controlled drug release, cell encapsulation, regenerative medicine, and tissue engineering.
一系列可注射的原位交联透明质酸/羧甲基纤维素基水凝胶（HA/CMC）是通过溶解氧的氧化作用通过二硫键制备的。结果表明，HA/CMC 水凝胶具有可调的胶凝时间、适当的流变性能、高溶胀比、良好的稳定性和持续的药物释放能力。HA/CMC 水凝胶的胶凝时间范围为 1.4 至 7.0 分钟，HA3/CMC3 水凝胶的储能模量、复合剪切模量、动态粘度和屈服应力的值约为 5869 Pa、5870 Pa、587 Pa·s 和 1969 Pa。HA1/CMC1、HA2/CMC2 和 HA3/CMC3 水凝胶在孵育 42 天后的降解百分比约为 60%、49%和 41%，载有 BSA 的 HA1/CMC1、HA2/CMC2 和 HA3/CMC3 药物释放水凝胶在 30 天后的体外累积释放百分比约为 99%、91%和 82%。一系列可注射的原位交联 HA/CMC 水凝胶表现出良好的综合性能，表明这些水凝胶可能在短期和中期控制药物释放、细胞包封、再生医学和组织工程等领域得到应用。
