透明质酸巯基改性的可注射水凝胶：合成、表征、药物释放、细胞摄取药物和抗癌活性。
Hyaluronic acid thiol modified injectable hydrogel: Synthesis, characterization, drug release, cellular drug uptake and anticancer activity.
机构信息
College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, 210023, China.
College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, 210023, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu, 224051, China.
出版信息
Carbohydr Polym. 2021 Feb 15;254:117286. doi: 10.1016/j.carbpol.2020.117286. Epub 2020 Oct 22.
Dimethyl sulfoxide (DMSO) is an excellent solvent for various types of anticancer drugs. Here, beyond that, it can participate in a disulfide bond crosslink between sulfhydryl (-SH) modified hyaluronic acid (HA-SH) molecules to form the hydrogel. Thus, during the above crosslink process, the dissolved drug in DMSO could be effectively loaded inside the hydrogels' porous structures as an injectable peritumoral implant. The loaded drugs can be sustained released through hydrogel swelling and degradation around the tumor tissue to suppress tumor growth. In this paper, the above hydrogel was used as a peritumoral drug-loaded implant for chemotherapeutics, photosensitizer, and photothermal reagent, respectively, for chemotherapy, photodynamic therapy, and photothermal therapy in cancer treatment. Therefore, this DMSO involved HA-SS-HA (HA, hyaluronic acid; -SS-, disulfide bond) hydrogel fabrication method is simple and widely applicable for drug-loaded peritumoral implant preparation.
二甲基亚砜（DMSO）是各种类型抗癌药物的优良溶剂。在这里，它可以进一步参与巯基（-SH）修饰的透明质酸（HA-SH）分子之间的二硫键交联，形成水凝胶。因此，在上述交联过程中，溶解在 DMSO 中的药物可以有效地作为可注射的瘤周植入物负载到水凝胶的多孔结构内。负载的药物可以通过水凝胶在肿瘤组织周围的肿胀和降解来持续释放，以抑制肿瘤生长。在本文中，上述水凝胶分别用作化疗药物、光敏剂和光热试剂的瘤周药物负载植入物，用于癌症治疗中的化疗、光动力疗法和光热疗法。因此，这种涉及 DMSO 的 HA-SS-HA（HA，透明质酸；-SS-，二硫键）水凝胶制备方法简单，广泛适用于瘤周药物负载植入物的制备。
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