Department of Physiology, The University of Melbourne, Melbourne, Australia; Department of Neuroscience, Monash University, Melbourne, Australia.
Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia.
J Neuroimmunol. 2019 May 15;330:159-169. doi: 10.1016/j.jneuroim.2019.03.004. Epub 2019 Mar 14.
Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.
多发性硬化症（MS）的特征是神经炎症浸润和中枢神经系统脱髓鞘。在 MS 的神经炎症病灶中，嘌呤能受体 P2X7R 的表达增加。尽管 P2X7R 与神经炎症有关，但它在 MS 背景下的确切作用尚不清楚，这也是本综述的基础。在本综述中，我们还介绍了 MS 的免疫病理学和炎症过程，重点介绍了 P2X7R 以及维生素 D 缺乏在这种情况下可能的免疫调节作用。
