Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Systematic Review Centre (SRC), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
BMJ Open. 2018 May 24;8(5):e020724. doi: 10.1136/bmjopen-2017-020724.
In recent times, hypertension has become one of the major public health concerns in both the developed and the developing world and is responsible for death due to heart diseases and stroke. The increasing trend of the prevalence of hypertension in low-income and middle-income countries (LMICs) and it's catastrophic consequences have made the phenomenon important to continue to investigate interventions for its prevention and control. Different dietary and lifestyle-related approaches have been recommended for the prevention of hypertension. The aim of this proposed review is to explore the available non-pharmacological interventions tried for the prevention of hypertension in LMICs.
Eight electronic databases will be searched covering the period between 1990 and 2016 to identify relevant studies and will be screened by two independent reviewers. The searched articles will be included for full-text extraction applying definitive inclusion and exclusion criteria. Appropriate critical appraisal tools including the Cochrane Handbook for Systematic Reviews of Interventions will be used to assess the risk of bias. Disagreement between the two reviewers will be resolved by a third reviewer. Narrative synthesis of the findings will be provided along with summaries of the intervention effect. A meta-analysis will be undertaken using the random-effects model where applicable. Heterogeneity between the studies will be assessed, and sensitivity analysis will be conducted based on study quality.
Approval from the institutional review board has been taken for this review. Findings will be summarised in a single manuscript.This review is an attempt to explore the available non-pharmacological approaches for the prevention of hypertension in LMICs. Findings from the review will highlight effective non-pharmacological measures for the prevention of hypertension to guide policy for future strategies.
CRD42017055423.
近年来，高血压已成为发达国家和发展中国家的主要公共卫生问题之一，是导致心脏病和中风死亡的主要原因。在中低收入国家（LMICs），高血压的患病率呈上升趋势，其灾难性后果使得继续研究预防和控制高血压的干预措施变得尤为重要。已经推荐了不同的饮食和与生活方式相关的方法来预防高血压。本研究旨在探讨在 LMICs 中用于预防高血压的可用非药物干预措施。
将搜索 1990 年至 2016 年期间的 8 个电子数据库，以确定相关研究，并由两名独立评审员进行筛选。将对搜索到的文章进行全文提取，并应用明确的纳入和排除标准。将使用适当的批判性评估工具，包括 Cochrane 干预系统评价手册，评估偏倚风险。两名评审员之间的分歧将由第三名评审员解决。将提供发现的叙述性综合，并总结干预效果。如有适用，将使用随机效应模型进行荟萃分析。将评估研究之间的异质性，并根据研究质量进行敏感性分析。
本研究已获得机构审查委员会的批准。研究结果将总结在一篇论文中。本综述旨在探讨在 LMICs 中预防高血压的可用非药物方法。综述结果将突出有效的非药物预防高血压措施，为未来的策略提供指导。
PROSPERO 注册号：CRD42017055423。
