Van Melkebeke Lukas, Barbosa-Breda João, Huygens Marc, Stalmans Ingeborg
Ophthalmic Res. 2018;60(3):139-151. doi: 10.1159/000488495. Epub 2018 May 24.
Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking.
To perform a literature review to assess the role of OCTA in glaucoma diagnosis and follow-up.
A database search was carried out using MEDLINE, Embase, and Web of Science, including all original works registered until July 23, 2017.
OCTA (1) has a high repeatability and reproducibility, (2) has good discriminatory power to differentiate normal eyes from glaucoma eyes, (3) is more strongly correlated with visual function than conventional OCT, (4) has good discriminatory power to differentiate early-glaucoma eyes from normal eyes (i.e., at least equal to that of OCT), (5) reaches a floor effect at a more advanced disease stage than OCT, and (6) is able to detect progression in glaucoma eyes.
OCTA shows potential to become a part of everyday glaucoma management.
青光眼是全球不可逆性失明的主要原因。目前有多种技术可用于青光眼患者的诊断和随访。光学相干断层扫描（OCT）血管造影（OCTA）是一种最近开发的技术，能够以快速、无创的方式对视网膜和脉络膜的微循环进行定量评估。尽管它是一项新技术，但在青光眼领域已经有了一些相关的出版物。然而，目前还缺乏对这些研究结果的总结。
进行一项文献综述，以评估OCTA在青光眼诊断和随访中的作用。
使用MEDLINE、Embase和Web of Science进行数据库检索，纳入截至2017年7月23日登记的所有原创研究。
OCTA（1）具有较高的重复性和再现性；（2）在区分正常眼和青光眼眼方面具有良好的鉴别能力；（3）与传统OCT相比，与视觉功能的相关性更强；（4）在区分早期青光眼眼和正常眼方面具有良好的鉴别能力（即至少与OCT相当）；（5）在疾病进展到更晚期时比OCT更早出现平台效应；（6）能够检测青光眼患者病情的进展。
OCTA显示出有望成为日常青光眼管理的一部分。
