Kurysheva N I, Maslova E V
Institute of Professional Development, Federal Medical-Biological Agency, 15 Gamalei St., Moscow, Russian Federation, 123098.
Vestn Oftalmol. 2016;132(5):98-102. doi: 10.17116/oftalma2016132598-102.
According to literature data, vascular dysfunction may well contribute to the development of glaucomatous optic neuropathy, which makes it reasonable to search for new imaging techniques capable of early diagnosis and monitoring of glaucoma through assessment of retinal, optic nerve head (ONH), and choroidal perfusion. Optical coherence tomography angiography (OCTA), a recently introduced method based on the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm, enables evaluation of both retinal and choroidal blood flow in peripapillary and macular areas. The first studies involving OCTA have revealed a decrease in retinal blood flow in glaucoma. It has also been shown that visual field indices correlate better with the peripapillary flow index than with morphometric parameters of the optic nerve head (ONH) and peripapillary retina. OCT angiography has great potential for ONH blood flow assessment during physiological tests, which is an important step towards understanding pathogenesis of glaucoma.
根据文献资料，血管功能障碍很可能促成青光眼性视神经病变的发展，这使得寻找能够通过评估视网膜、视神经乳头（ONH）和脉络膜灌注来早期诊断和监测青光眼的新成像技术成为合理之举。光学相干断层扫描血管造影（OCTA）是一种基于分裂谱幅度去相关血管造影（SSADA）算法的新近引入的方法，能够评估视乳头周围和黄斑区域的视网膜及脉络膜血流。首批涉及OCTA的研究已揭示青光眼患者视网膜血流减少。研究还表明，视野指标与视乳头周围血流指数的相关性优于与视神经乳头（ONH）和视乳头周围视网膜形态学参数的相关性。OCT血管造影在生理测试期间评估ONH血流方面具有巨大潜力，这是迈向了解青光眼发病机制的重要一步。
