Zhou Kaiyu, Yue Peng, Ma Fan, Yan Hualin, Zhang Yi, Wang Chuan, Qiu Dajian, Hua Yimin, Li Yifei
Department of Pediatrics, West China Second University Hospital, Sichuan University Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University Program for Changjiang Scholars and Innovative Research Team in University, West China Second University Hospital, Sichuan University West China Medical School, Sichuan University, Chengdu, Sichuan, China.
Medicine (Baltimore). 2018 May;97(21):e10712. doi: 10.1097/MD.0000000000010712.
To interpret the various associations between miRNA polymorphisms and cardiovascular diseases (CVD).
Literature search has identified relevant studies up to June 2016. A meta-analysis was performed followed the guidelines from the Cochrane review group and the PRISMA statement. Studies were identified by searching the Cochrane Library, EMBASE, PUBMED and WHO clinical trials registry center. A meta-analysis has been done with a fixed/random-effect model using STATA 14.0, which also has been used to estimate the publication bias and meta-regression.
The results from 11 case-control studies were included. The miR-146a G/C makes a contribution to the causing of CVD as recessive genetic model. And the miR-499 G/A raised the risks of cardiomyopathy, however it could still accelerate the procedure of CVD combined with myocardial infraction. At this point, we consider that it could deepen the adverse of outcomes from coronary artery disease (CAD), but it's hard to draw an association between miR-499 G/A and CAD. At last the miR-196a2 T/C demonstrated a contrary role between development problem and metabolic issues, which protects the development procedure and impairs the metabolism to cause different disease phenotypes.
Despite inter-study variability, the polymorphisms from miR-146a, miR-499 and miR-196a2 have impacts on cardiovascular disease. Each type of miRNA has individual role in either cardiac development or the origins of CVD.
解读微小RNA（miRNA）多态性与心血管疾病（CVD）之间的各种关联。
通过文献检索确定截至2016年6月的相关研究。按照Cochrane综述组和PRISMA声明的指南进行荟萃分析。通过检索Cochrane图书馆、EMBASE、PUBMED和世界卫生组织临床试验注册中心来识别研究。使用STATA 14.0软件采用固定/随机效应模型进行荟萃分析，该软件也用于评估发表偏倚和进行元回归分析。
纳入了11项病例对照研究的结果。miR-146a G/C作为隐性遗传模型对CVD的发生有影响。miR-499 G/A增加了心肌病的风险，然而在合并心肌梗死时它仍可加速CVD进程。此时，我们认为它可能会加重冠状动脉疾病（CAD）的不良后果，但很难得出miR-499 G/A与CAD之间的关联。最后，miR-196a2 T/C在发育问题和代谢问题之间表现出相反的作用，它保护发育过程而损害代谢，从而导致不同的疾病表型。
尽管研究间存在差异，但miR-146a、miR-499和miR-196a2的多态性对心血管疾病有影响。每种类型的miRNA在心脏发育或CVD的发病机制中都有各自的作用。
