Research Unit of Biomedicine, and Biocenter of Oulu, Oulu University, 90014, Oulu, Finland.
Hypertension Clinic, Internal Medicine, Hospital de Sagunto, Valencia, Spain.
Sci Rep. 2018 May 23;8(1):8045. doi: 10.1038/s41598-018-25755-4.
Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.
颈股脉搏波速度((cf)PWV)是动脉僵硬度的一种测量方法，可预测心血管疾病。我们假设体力活动(PA)的量与 2 型糖尿病(T2D)患者的动脉僵硬度降低有关。在分析中纳入了来自 1945 年奥卢出生队列的 570 名受试者。(cf)PWV 通过非侵入性平板压力测量法确定。进行口服葡萄糖耐量试验并分析 LDL 和 HDL 胆固醇。用腕戴加速度计在两周内每天记录 PA。葡萄糖代谢受损(IGM)和 T2D 受试者的(cf)PWV 值高于血糖正常受试者(P < 0.001)。PA、空腹和 2 小时血糖以及 HbA1c 与(cf)PWV 显著相关，但 HDL 或 LDL 胆固醇则没有。在多元回归分析中，T2D 受试者的 2 小时血糖、心率和饮酒量对(cf)PWV 有独立影响。T2D 和 IGM 与(cf)PWV 显著相关。有趣的是，脂质对(cf)PWV 没有额外的影响。每天行走超过 10000 步的受试者的(cf)PWV 比每天行走少于 6000 步的受试者低 0.2 m/s。在男性中，T2D、心率升高和饮酒与老年受试者的主动脉僵硬度增加有关。
