Bioresource Engineering Research Group (BioERG), Faculty of Applied Sciences, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 8000, South Africa.
Department of Biomedical Science, Faculty of Health and Wellness, Cape Peninsula University of Technology, Cape Town 7535, South Africa.
Int J Environ Res Public Health. 2020 Nov 24;17(23):8735. doi: 10.3390/ijerph17238735.
Dyslipidaemia, an irregular aggregate of lipids in the blood is common in diabetes and cardiovascular disease sufferers. A cross-sectional study on the prevalence of dyslipidaemia was performed among type 2 diabetes mellitus (T2DM) patients in the Western Cape, South Africa. Patients ( = 100) that participated in the study were within the age range of 19-68 years, of whom 89% were observed to have serum lipid abnormalities. Out of the 100 patients, 56%, 64%, 61%, and 65% were recorded to have high total cholesterol (TC), hypertriglycemia, increased low-density lipoproteins cholesterol (LDL-C), and reduced high-density lipoproteins cholesterol (HDL-C), respectively. In male diabetic patients, a marked prevalence of (94%) dyslipidemia was noted, of which 52% were affected by high TC (5.3-7.9 mmol/L), with 70% having a high level of triglyceride (TG) [1.72-7.34 mmol/L], while 60% had a high LDL-C (3.1-5.5 mmol/L), including 78% with low HDL-C (0.7-1.1 mmol/L). In comparison, 84% of diabetic females had dyslipidemia, with high TC (5.1-8.1 mmol/L), hypertriglycemia (1.73-8.63 mmol/L), high LDL-C (3.1-5.6 mmol/L), and low levels of HDL-C (0.8-1.1 mmol/L) affecting 60%, 58%, 62%, and 52% of the patients, respectively. This study showed the importance of screening and the regular surveillance of dyslipidaemia in T2DM patients as there is a paucity of data on it in Africa.
血脂异常是一种血液中脂质异常聚集的病症，在糖尿病和心血管疾病患者中较为常见。本研究对南非西开普省 2 型糖尿病（T2DM）患者的血脂异常患病率进行了横断面研究。参与本研究的患者年龄在 19-68 岁之间，其中 89%的患者存在血脂异常。在 100 名患者中，分别有 56%、64%、61%和 65%的患者存在总胆固醇（TC）升高、高甘油三酯血症、低密度脂蛋白胆固醇（LDL-C）升高和高密度脂蛋白胆固醇（HDL-C）降低。在男性糖尿病患者中，血脂异常的患病率显著（94%），其中 52%的患者 TC 升高（5.3-7.9mmol/L），70%的患者甘油三酯（TG）升高（1.72-7.34mmol/L），60%的患者 LDL-C 升高（3.1-5.5mmol/L），包括 78%的患者 HDL-C 降低（0.7-1.1mmol/L）。相比之下，84%的女性糖尿病患者存在血脂异常，其中 TC 升高（5.1-8.1mmol/L）、高甘油三酯血症（1.73-8.63mmol/L）、LDL-C 升高（3.1-5.6mmol/L）和 HDL-C 降低（0.8-1.1mmol/L）分别影响 60%、58%、62%和 52%的患者。本研究表明，在非洲，针对 T2DM 患者血脂异常的筛查和定期监测非常重要，但目前这方面的数据非常有限。
