College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore.
Adv Sci (Weinh). 2024 Oct;11(39):e2401310. doi: 10.1002/advs.202401310. Epub 2024 Aug 21.
Hydrogen (H) therapy is an emerging, novel, and safe therapeutic modality that uses molecular hydrogen for effective treatment. However, the impact of H therapy is limited because hydrogen molecules predominantly depend on the systemic administration of H gas, which cannot accumulate at the lesion site with high concentration, thus leading to limited targeting and utilization. Biomaterials are developed to specifically deliver H and control its release. In this review, the development process, stimuli-responsive release strategies, and potential therapeutic mechanisms of biomaterial-based H therapy are summarized. H therapy. Specifically, the produced H from biomaterials not only can scavenge free radicals, such as reactive oxygen species (ROS) and lipid peroxidation (LPO), but also can inhibit the danger factors of initiating diseases, including pro-inflammatory cytokines, adenosine triphosphate (ATP), and heat shock protein (HSP). In addition, the released H can further act as signal molecules to regulate key pathways for disease treatment. The current opportunities and challenges of H-based therapy are discussed, and the future research directions of biomaterial-based H therapy for clinical applications are emphasized.
氢气（H）治疗是一种新兴的、新颖的、安全的治疗方式，利用分子氢进行有效治疗。然而，H 治疗的效果有限，因为氢气分子主要依赖于 H 气体的全身给药，不能在病变部位以高浓度积聚，从而导致靶向性和利用率有限。生物材料被开发出来专门输送 H 并控制其释放。在这篇综述中，总结了基于生物材料的 H 治疗的发展过程、刺激响应释放策略和潜在的治疗机制。具体来说，生物材料产生的 H 不仅可以清除自由基，如活性氧（ROS）和脂质过氧化（LPO），还可以抑制引发疾病的危险因子，包括促炎细胞因子、三磷酸腺苷（ATP）和热休克蛋白（HSP）。此外，释放的 H 可以进一步作为信号分子来调节疾病治疗的关键途径。讨论了基于 H 的治疗的当前机会和挑战，并强调了生物材料基 H 治疗的未来研究方向，以应用于临床。
