Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Department of Ophthalmology, Graduate School of Medical Sciences, Akita University, Akita, 010-8543, Japan.
Sci Rep. 2018 May 23;8(1):8070. doi: 10.1038/s41598-018-26231-9.
In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagnosed with typical RP. Visual acuity (VA), visual field using a Humphrey Field Analyzer with the central 10-2 SITA-Standard program, and optical coherence tomography measurements were obtained. The slopes, which were derived from serial values of mean deviation (MD), macular sensitivity (MS), or foveal sensitivity (FS) obtained for each eye by a linear mixed model, were used for analysis. MS and FS were calculated as the average retinal sensitivity of 12 and 4 central points respectively. There were statistically significant interactions of times with levels of the central subfield thickness (CST) on the slopes of MS and FS. Compared to the eyes without macular complications, the eyes with macular complications had steeper MD, MS and FS slopes, and this interaction was no significant, but marginal trend for the MS or FS slope (P = 0.10, 0.05, respectively). The central retinal sensitivity (i.e., MS and FS) slopes calculated were effective indices of the progression of central visual function in RP.
为了阐明色素性视网膜炎（RP）的疾病进展及其相关因素，需要可靠的数据来反映 RP 患者中心视力功能的变化。在这项纵向研究中，我们检查了 118 名被诊断为典型 RP 的患者。使用 Humphrey 视野分析仪（中央 10-2 SITA-Standard 程序）获取了视力（VA）、视野和光相干断层扫描（OCT）测量值。通过线性混合模型获得每个眼睛的平均偏差（MD）、黄斑敏感性（MS）或中央敏感性（FS）的系列值，使用斜率来进行分析。MS 和 FS 分别计算为 12 个和 4 个中央点的视网膜平均敏感性。MS 和 FS 斜率与中央子场厚度（CST）水平之间存在统计学显著的时间交互作用。与没有黄斑并发症的眼睛相比，有黄斑并发症的眼睛的 MD、MS 和 FS 斜率更陡峭，尽管这种交互作用对于 MS 或 FS 斜率没有显著意义，但呈边际趋势（P=0.10，0.05）。计算得出的中央视网膜敏感性（即 MS 和 FS）斜率是 RP 中心视力功能进展的有效指标。
