Multidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, Second University of Naples, Naples, Italy.
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
Br J Ophthalmol. 2014 Jul;98(7):946-50. doi: 10.1136/bjophthalmol-2013-304082. Epub 2014 Feb 13.
To investigate the prevalence of macular abnormalities in a large Caucasian cohort of patients affected by retinitis pigmentosa (RP).
A retrospective study was performed by reviewing the medical records and optical coherence tomography (OCT) scans in a cohort of 581 RP patients in order to assess the presence of macular abnormalities -that is, cystoid macular oedema (CMO), epiretinal membrane (ERM), vitreo-macular traction syndrome, and macular hole.
Macular abnormalities were observed in 524 (45.1%) out of the 1161 examined eyes. The most frequent abnormality was CMO, observed in 237 eyes (20.4%) from 133 patients (22.9%), followed by ERM, assessed in 181 eyes (15.6%) from 115 patients (19.8%). Moreover, vitreo-retinal abnormalities were significantly (p<0.05) associated with older age, cataract surgery, or cataract. CMO appeared to be significantly (p<0.05) associated with female gender, autosomic dominant inheritance pattern, and cataract.
Macular abnormalities are more frequent in RP compared to the general population. For that reason, screening RP patients with OCT is highly recommended to follow-up the patients, evaluate the natural history of disease, and identify those patients who could benefit from current or innovative therapeutic strategies.
调查大样本白种人视网膜色素变性（RP）患者黄斑异常的患病率。
通过回顾 581 例 RP 患者的病历和光学相干断层扫描（OCT）图像，进行回顾性研究，以评估黄斑异常的存在情况，即囊样黄斑水肿（CMO）、视网膜前膜（ERM）、玻璃体黄斑牵引综合征和黄斑裂孔。
在 1161 只受检眼中，有 524 只（45.1%）出现黄斑异常。最常见的异常是 CMO，在 133 例（22.9%）患者的 237 只眼中观察到（20.4%），其次是 ERM，在 115 例（19.8%）患者的 181 只眼中评估到（15.6%）。此外，玻璃体视网膜异常与年龄较大、白内障手术或白内障显著相关（p<0.05）。CMO 似乎与女性、常染色体显性遗传模式和白内障显著相关（p<0.05）。
与一般人群相比，RP 患者黄斑异常更为常见。因此，建议对 RP 患者进行 OCT 筛查，以对患者进行随访、评估疾病的自然史，并识别那些可能受益于现有或创新治疗策略的患者。
