Department of Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Institute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.
PLoS One. 2018 May 24;13(5):e0198027. doi: 10.1371/journal.pone.0198027. eCollection 2018.
β2-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether B2M leads to depressive- and anxiety-like behaviors. We found that 6 days after intracerebroventricular injection with B2M (0.3 μg), the immobility times of rats in the tail suspension test and the forced swimming test were increased, the swimming and climbing time in the forced swimming test was decreased, and the latency to feed in the novelty-suppressed feeding test was increased, indicating that B2M induces depressive-like behaviors. In addition, in the elevated plus maze test, B2M-treated rats displayed obvious decline in the number of entries into and the proportion of time spent in the open arm, while the number of total arm entries was no change, which indicated that B2M induces anxiety-like behaviors. Our present findings suggest that target B2M might represent a novel approach for treatment of depression and anxiety.
β2-微球蛋白（B2M）是主要组织相容性复合体 I 类（MHC I）分子的轻链，已被发现会损害海马神经发生。基于海马神经发生紊乱在抑郁和焦虑过程中的关键作用，本研究旨在探讨 B2M 是否导致抑郁和焦虑样行为。我们发现，在脑室内注射 B2M（0.3μg）6 天后，大鼠在悬尾试验和强迫游泳试验中的不动时间增加，在强迫游泳试验中的游泳和攀爬时间减少，新异食物抑制进食试验中的进食潜伏期增加，表明 B2M 诱导抑郁样行为。此外，在高架十字迷宫试验中，B2M 处理的大鼠进入和在开放臂中花费的时间比例明显减少，而总臂进入次数没有变化，这表明 B2M 诱导焦虑样行为。我们目前的研究结果表明，靶向 B2M 可能代表治疗抑郁和焦虑的一种新方法。
