海洋代谢产物 prorocentin-4 的合成研究：C1-C23 片段的合成。
Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1-C23 fragment.
机构信息
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
出版信息
Org Biomol Chem. 2018 Jun 6;16(22):4191-4194. doi: 10.1039/c8ob00388b.
PMID:29796520
Abstract
A synthetic study of the construction of the C1-C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner-Wadsworth-Emmons (HWE) olefination reaction as key steps.
摘要
描述了一种新型线性聚酮前原促皮质素-4 的 C1-C23 片段的合成研究。合成的重点包括酸催化环氧化合物开环、吉尔曼反应、Pd(OH)2 催化将伯炔丙醇转化为醛、Oxa-Michael 环化以及霍纳-沃兹沃思-埃蒙斯（HWE）烯烃化反应等关键步骤。
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