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通过串联分子内迈克尔环化-HWE烯化反应合成（±）-油橄榄苦素

Synthesis of (+/-)-Oleocanthal via a Tandem Intramolecular Michael Cyclization-HWE Olefination.

作者信息

English Brandon J, Williams Robert M

机构信息

Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.

出版信息

Tetrahedron Lett. 2009 Jun 10;50(23):2713. doi: 10.1016/j.tetlet.2009.03.145.

DOI:10.1016/j.tetlet.2009.03.145
PMID:20161637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2817976/
Abstract

A synthesis of racemic oleocanthal has been accomplished in eleven steps from 1,3 propanediol by a key tandem intramolecular Michael cyclization-Horner Wadsworth Emmons olefination.

摘要

通过关键的分子内迈克尔环化-霍纳尔-沃兹沃思-埃蒙斯烯烃化反应，从1,3-丙二醇出发，经十一步反应完成了外消旋油橄榄苦素的合成。