用于组织工程的增强型混合胶原海绵
Reinforced Hybrid Collagen Sponges for Tissue Engineering.
作者信息
Bardakova K N, Grebenik E A, Istranova E V, Istranov L P, Gerasimov Yu V, Grosheva A G, Zharikova T M, Minaev N V, Shavkuta B S, Dudova D S, Kostyuk S V, Vorob'eva N N, Bagratashvili V N, Timashev P S, Chailakhyan R K
机构信息
Institute of Photonics Technologies, Federal Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Moscow, Russia.
Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2018 May;165(1):142-147. doi: 10.1007/s10517-018-4116-8. Epub 2018 May 24.
We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young's modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs.
我们通过激光光聚合制备了一种基于胶原海绵和反应性聚丙交酯的各向异性材料。与胶原海绵相比，胶原与反应性聚丙交酯的结合提高了所形成基质的抗生物降解性，而基质上具有不同力学特性和细胞亲和力的位点的存在，在细胞培养过程中提供了定向的细胞生长。结果表明，胶原海绵增强7倍可提高杂化基质的平均杨氏模量，而不影响其细胞毒性。所开发的基质可使细胞沿增强线黏附并增殖，可用于制造组织工程构建体。
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