Houghton L A, Read N W
Sub-department of Human Gastrointestinal Physiology and Nutrition, Royal Hallamshire Hospital, Sheffield, UK.
Aliment Pharmacol Ther. 1987 Oct;1(5):401-8. doi: 10.1111/j.1365-2036.1987.tb00640.x.
Paired studies were carried out on 18 healthy male volunteers (20.9 +/- 1.9 years; mean +/- S.D.) to compare the effect of oral doses of the H2-receptor antagonists, ranitidine and cimetidine, on the rate of gastric emptying of radiolabelled solid and liquid test meals. Oral administration of ranitidine 300 mg accelerated the emptying of a liquid meal from the stomach, but it had no significant effect on the rate of emptying of a solid meal. Oral administration of either 400 or 800 mg cimetidine did not alter the rate of emptying of either the liquid or the solid meals from the stomach.
对18名健康男性志愿者（20.9±1.9岁；平均值±标准差）进行了配对研究，以比较口服H2受体拮抗剂雷尼替丁和西咪替丁对放射性标记固体和液体试验餐胃排空率的影响。口服300毫克雷尼替丁可加速液体餐从胃中的排空，但对固体餐的排空率无显著影响。口服400毫克或800毫克西咪替丁均未改变液体餐或固体餐从胃中的排空率。
