应用电位断层扫描术测量西咪替丁和雷尼替丁后胃排空率的比较。
A comparison of gastric emptying rate after cimetidine and ranitidine measured by applied potential tomography.
作者信息
Mushambi M C, Trotter T N, Barker P, Rowbotham D J
机构信息
University Department of Anaesthesia, Leicester Royal Infirmary.
出版信息
Br J Clin Pharmacol. 1992 Sep;34(3):278-80. doi: 10.1111/j.1365-2125.1992.tb04139.x.
Abstract
Gastric emptying was measured using applied potential tomography (APT) after crossover administration of 800 mg cimetidine and 300 mg ranitidine orally. Ten volunteers were studied, each on two occasions. Two hours after taking ranitidine or cimetidine, the volunteer was given a liquid and gastric emptying was measured over 60 min. There was a small but statistically significant delay in gastric emptying following ranitidine compared with cimetidine (P less than 0.04). The median (range) time to 50% emptying (t50) was 24 (15-60) min after ranitidine compared with 22 (15-46) min after cimetidine.
摘要
在口服800毫克西咪替丁和300毫克雷尼替丁交叉给药后，使用应用电位断层扫描（APT）测量胃排空。研究了10名志愿者，每人进行两次测量。服用雷尼替丁或西咪替丁两小时后，给志愿者服用一种液体，并在60分钟内测量胃排空情况。与西咪替丁相比，雷尼替丁后胃排空有轻微但具有统计学意义的延迟（P小于0.04）。雷尼替丁后达到50%排空的中位（范围）时间（t50）为24（15 - 60）分钟，而西咪替丁后为22（15 - 46）分钟。
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