Logan R F, Forrest J A, McLoughlin G P, Lidgard G, Heading R C
Digestion. 1978;18(3-4):220-6. doi: 10.1159/000198205.
Paired studies of gastric emptying were performed in 10 healthy volunteers using a scintiscanning technique which provides information about the rate of emptying of both the liquid and solid components of a standard meal. Emptying rates of both components were not significantly different after oral administration of 400 mg cimetidine than after placebo. The increase in serum gastrin concentration produced by the meal was significantly greater after cimetidine than after placebo but there was no relationship between individual cimetidine-placebo differences in gastrin response and the corresponding cimetidine-placebo differences in rates of emptying. A positive correlation was demonstrated between the gastric emptying rate of the liquid component and the 1 h cimetidine absorption, indicating that normal individual variation in gastric emptying is probably responsible for much of the normal individual variation in the rate of cimetidine absorption.
采用闪烁扫描技术对10名健康志愿者进行了胃排空配对研究，该技术可提供有关标准餐中液体和固体成分排空速率的信息。口服400毫克西咪替丁后的两种成分排空率与服用安慰剂后相比无显著差异。用餐后西咪替丁引起的血清胃泌素浓度升高显著大于安慰剂，但胃泌素反应中西咪替丁与安慰剂个体差异和相应的西咪替丁与安慰剂排空率差异之间无相关性。液体成分的胃排空率与西咪替丁1小时吸收之间呈正相关，表明胃排空的正常个体差异可能是西咪替丁吸收速率正常个体差异的主要原因。
