Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Norwich Medical School, University of East Anglia, Norwich, UK.
Soc Psychiatry Psychiatr Epidemiol. 2018 Oct;53(10):1133-1140. doi: 10.1007/s00127-018-1534-x. Epub 2018 May 23.
There is consistent evidence that socio-environmental factors measured at an area-level, such as ethnic density, urban environment and deprivation are associated with psychosis risk. However, whether area-level socio-environmental factors are associated with outcomes following psychosis onset is less clear. This study aimed to examine whether the number of inpatient days used by people presenting to mental health services for psychosis was associated with five key area-level socio-environmental factors: deprivation, ethnic density, social capital, population density and social fragmentation.
Using a historical cohort design based on electronic health records from the South London and Maudsley NHS Trust Foundation electronic Patient Journey System, people who presented for the first time to SLAM between 2007 and 2010 with psychosis were included. Structured data were extracted on age at presentation, gender, ethnicity, residential area at first presentation and number of inpatient days over 5 years of follow-up. Data on area-level socio-environmental factors taken from published sources were linked to participants' residential addresses. The relationship between the number of inpatient days and each socio-environmental factor was investigated in univariate negative binomial regression models with time in contact with services treated as an offset variable.
A total of 2147 people had full data on area level outcomes and baseline demographics, thus, could be included in the full analysis. No area-level socio-environmental factors were associated with inpatient days.
Although a robust association exists between socio-environmental factors and psychosis risk, in this study we found no evidence that neighbourhood deprivation was linked to future inpatient admissions following the onset of psychosis. Future work on the influence of area-level socio-environmental factors on outcome should examine more nuanced outcomes, e.g. recovery, symptom trajectory, and should account for key methodological challenges, e.g. accounting for changes in address.
有充分证据表明,在区域层面上测量的社会环境因素,如种族密度、城市环境和贫困,与精神病风险有关。然而,区域层面的社会环境因素是否与精神病发病后的结果有关尚不清楚。本研究旨在检验人们因精神病到精神卫生服务机构就诊的住院天数是否与五个关键的区域层面社会环境因素有关:贫困、种族密度、社会资本、人口密度和社会碎片化。
本研究采用基于南伦敦和莫兹利国民保健信托基金会电子患者就诊系统电子病历的历史队列设计,纳入了 2007 年至 2010 年期间首次在 SLAM 就诊的精神病患者。从结构化数据中提取了就诊时的年龄、性别、种族、首次就诊时的居住地址以及 5 年随访期间的住院天数。从已发表的资料中获取的区域层面社会环境因素数据与参与者的居住地址相关联。在单变量负二项回归模型中,以接触服务的时间为协变量,调查住院天数与每个社会环境因素之间的关系。
共有 2147 人具有完整的区域层面结果和基线人口统计学数据,因此可以纳入全分析。没有发现区域层面的社会环境因素与住院天数有关。
尽管社会环境因素与精神病风险之间存在着强有力的关联,但在本研究中,我们没有发现贫困与精神病发病后的住院人数有关。未来关于区域层面社会环境因素对结果的影响的研究应该更细致地研究结果,例如恢复、症状轨迹等,并且应该考虑到关键的方法学挑战,例如考虑地址的变化。