奥美拉唑对正常受试者食管下段功能的影响。

Effect of omeprazole on lower oesophageal function in normal subjects.

作者信息

Chakraborty T K, De Caestecker J S, Pryde A, Heading R C

机构信息

University Department of Medicine, Royal Infirmary of Edinburgh, UK.

出版信息

Aliment Pharmacol Ther. 1987 Dec;1(6):627-31. doi: 10.1111/j.1365-2036.1987.tb00648.x.

DOI:10.1111/j.1365-2036.1987.tb00648.x

PMID:2979690

Abstract

In a double-blind crossover study, lower oesophageal sphincter pressure (LOSP) and distal oesophageal motility were studied in eight healthy volunteers following a single intravenous dose of omeprazole or placebo. Lower oesophageal sphincter pressure was determined before and at intervals up to 120 min after intravenous administration of 40 mg omeprazole or placebo. No effects on LOSP or distal oesophageal motility were observed.

摘要

在一项双盲交叉研究中，对8名健康志愿者单次静脉注射奥美拉唑或安慰剂后，研究了食管下括约肌压力（LOSP）和食管远端动力。在静脉注射40mg奥美拉唑或安慰剂之前及之后直至120分钟的间隔时间测定食管下括约肌压力。未观察到对LOSP或食管远端动力有影响。