Adewusi Joy K, Hadjivassiliou Marios, Vinagre-Aragón Ana, O'Connor Karen Ruth, Khan Aijaz, Grünewald Richard Adam, Zis Panagiotis
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK.
Acta Neurol Belg. 2018 Sep;118(3):445-450. doi: 10.1007/s13760-018-0947-3. Epub 2018 May 23.
Neuropathic symptoms are commonly reported in Parkinson's disease (PD), but robust data on the epidemiology of such symptoms are lacking. The present study sought to investigate the prevalence and determinants of peripheral sensory neuropathic symptoms (PSNS) in idiopathic PD (IPD) and ascertain the effects of such symptoms on the patients' quality of life (QoL).
Patients with IPD and age-matched and gender-matched controls were screened for neuropathic symptoms using the Michigan Neuropathy Screening Instrument. The impact of neuropathic symptoms on QoL was investigated using the 36-Item Short Form Survey.
Fifty-two patients and 52 age-matched and gender-matched controls were recruited. PSNS were reported more frequently in patients with IPD than in the control subjects (57.7 versus 28.8%, p = 0.003). No significant relationships were found between PD-related clinical characteristics (i.e. disease severity and duration, duration of exposure to levodopa) and the presence of PSNS. Significant correlations were found between the number of PSNS and physical functioning (Spearman's Rho - 0.351), even after adjusting for age, gender and Hoehn and Yahr score.
Our results support the notion of a greater prevalence of PSNS in IPD patients as compared to the general population, which, at least in part, may be secondary to large and/or small fibre peripheral neuropathy. This warrants further investigation in larger studies that include detailed neurophysiological assessments.
帕金森病（PD）患者常报告有神经病变症状，但缺乏关于此类症状流行病学的确切数据。本研究旨在调查特发性帕金森病（IPD）患者外周感觉神经病变症状（PSNS）的患病率及其决定因素，并确定此类症状对患者生活质量（QoL）的影响。
使用密歇根神经病变筛查工具对IPD患者以及年龄和性别匹配的对照组进行神经病变症状筛查。使用36项简短调查问卷调查神经病变症状对生活质量的影响。
招募了52例患者以及52名年龄和性别匹配的对照者。IPD患者中PSNS的报告频率高于对照者（57.7%对28.8%，p = 0.003）。未发现与PD相关的临床特征（即疾病严重程度和病程、左旋多巴暴露时间）与PSNS的存在之间存在显著关系。即使在调整年龄、性别以及Hoehn和Yahr评分后，PSNS的数量与身体功能之间仍存在显著相关性（Spearman相关系数-0.351）。
我们的结果支持以下观点，即与普通人群相比，IPD患者中PSNS的患病率更高，这至少部分可能继发于大纤维和/或小纤维周围神经病变。这需要在包括详细神经生理学评估的更大规模研究中进一步调查。
