Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of General Medicine, Shiga Medical Center for Children, Shiga, Japan.
Pediatr Blood Cancer. 2018 Oct;65(10):e27250. doi: 10.1002/pbc.27250. Epub 2018 May 24.
Compared to cerebral radiation-induced cavernous hemangiomas (RICHs), little is known about intraspinal RICHs. A 13-year-old male suddenly developed symptomatic spinal hemorrhage eight years after hematopoietic stem cell transplantation using a total body irradiation (TBI) based myeloablative regimen. A solitary small hemangioma was detected on follow-up T2 star weighted magnetic resonance imaging of the spine. His neurological symptoms gradually improved with supportive treatment and rehabilitation, although he experienced rebleeding 2 years later. Intraspinal RICH is very rare but should be recognized as a possible late adverse effect in pediatric patients who received TBI.
与脑放射性诱导性海绵状血管瘤（RICH）相比，人们对脊髓内 RICH 知之甚少。一名 13 岁男性在接受基于全身照射（TBI）的清髓性治疗方案的造血干细胞移植 8 年后，突然出现症状性脊髓出血。在后续的脊柱 T2 星加权磁共振成像检查中发现单个小的血管瘤。他的神经症状通过支持治疗和康复逐渐改善，尽管他在 2 年后再次发生出血。脊髓内 RICH 非常罕见，但在接受 TBI 的儿科患者中，应将其视为一种可能的迟发性不良反应。
