Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
Department of Biomedical Photonics & Engineering, Hamamatsu University School of Medicine, Japan.
Intern Med. 2024 Oct 15;63(20):2853-2856. doi: 10.2169/internalmedicine.2898-23. Epub 2024 Feb 26.
Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative diseases that occur after solid organ transplantation or hematopoietic stem cell transplantation (HSCT). The development of PTLD is often associated with reactivation of Epstein-Barr virus (EBV). A 26-year-old woman with a history of HSCT and total-body irradiation developed spinal cord hemorrhage from a radiation-induced cavernous hemangioma (RICH) shortly after the development of classical Hodgkin lymphoma PTLD with EBV reactivation. Although little is known about the factors leading to hemorrhagic events from spinal cord RICH, we suspect that EBV reactivation may have been a factor contributing to the hemorrhage in the present case.
移植后淋巴组织增生性疾病（PTLD）是发生于实体器官移植或造血干细胞移植（HSCT）后的淋巴组织增生性疾病。PTLD 的发生通常与 EBV 的再激活有关。一位 26 岁的女性，有 HSCT 和全身照射史，在 EBV 再激活的经典霍奇金淋巴瘤 PTLD 发生后不久，因放射诱导的海绵状血管畸形（RICH）而发生脊髓出血。尽管对于导致脊髓 RICH 发生出血事件的因素知之甚少，但我们怀疑 EBV 的再激活可能是导致本病例出血的一个因素。
