Stendahl U, Wagenius G, Strang P, Tribukait B
Department of Gynecologic Oncology, Region Hospital, University Hospital, Umeå, Sweden.
In Vivo. 1988 Mar-Apr;2(2):123-7.
In a prospective study including 185 women with endometrial adenocarcinoma, the DNA-content and the S-phase rate were measured by flow cytometry. The tumors of 138 (75%) patients were peridiploid and those of 47 (25%) were grossly aneuploid. Aneuploid tumors were more common in poorly differentiated tumors than in well and moderately differentiated tumors (p less than 0.0001). S-phase rates were evaluable in 148 (80%) tumors. High S-phase rates were more frequent in stages III + IV than in stages I + II (p less than 0.05) and were also more common in poorly differentiated tumors than in moderately and well differentiated tumors (p less than 0.05). Ploidy levels and S-phase rates were not significantly correlated with age or menopausal status. During the follow-up time (6 to 38 months), 19 patients died of their disease. The number of deaths registered was significantly higher among patients with aneuploid tumors than among patients with peridiploid tumors (p less than 0.002). The proportion of tumors with high S-phase rates was significantly higher than that of tumors with low S-phase rates (p less than 0.0001). These preliminary results indicate that patients with aneuploid tumors or tumors with high S-phase rates are at high risk for early recurrences.
在一项纳入185例子宫内膜腺癌患者的前瞻性研究中，通过流式细胞术测量DNA含量和S期比率。138例（75%）患者的肿瘤为亚二倍体，47例（25%）患者的肿瘤为明显非整倍体。非整倍体肿瘤在低分化肿瘤中比在高分化和中分化肿瘤中更常见（p<0.0001）。148例（80%）肿瘤可评估S期比率。S期比率高在Ⅲ+Ⅳ期比在Ⅰ+Ⅱ期更常见（p<0.05），在低分化肿瘤中也比在中分化和高分化肿瘤中更常见（p<0.05）。倍体水平和S期比率与年龄或绝经状态无显著相关性。在随访期（6至38个月）内，19例患者死于该疾病。非整倍体肿瘤患者的死亡登记数显著高于亚二倍体肿瘤患者（p<0.002）。S期比率高的肿瘤比例显著高于S期比率低的肿瘤比例（p<0.0001）。这些初步结果表明，非整倍体肿瘤或S期比率高的肿瘤患者早期复发风险高。
