Wagenius G, Strang P, Boman K, Tribukait B, Stendahl U
Department of Oncology, Uppsala University, Akademiska Sjukhuset, Sweden.
In Vivo. 1988 May-Aug;2(3-4):243-5.
The DNA content and the S-phase rate were determined by flow cytometry in 129 women with endometrial adenocarcinoma in stages I and II. Aneuploidy and elevated S-phase rates were statistically correlated to loss of histopathologic differentiation. After preoperative intracavitary irradiation and surgery, the occurrence of residual myometrial invasion was studied. Residual myometrial invasion was found in 28 (22%) cases. In 17 (17%) of the peri-diploid (1.8c-2.2c) and in 11 (38%) of the aneuploid tumors, respectively, the myometrium was invaded (p less than 0.05). No statistical correlation was found between mean S-phase rate and myometrial invasion. The difference in residual myometrial invasion found between aneuploid and peri-diploid tumors after intracavitary treatment may reflect a primary difference in the tendency to invade the myometrium or a difference in responsiveness to radiotherapy.
采用流式细胞术对129例Ⅰ期和Ⅱ期子宫内膜腺癌患者的DNA含量及S期比率进行了测定。非整倍体和升高的S期比率与组织病理学分化程度降低在统计学上相关。术前腔内照射和手术后，对残留肌层浸润的发生情况进行了研究。发现28例（22%）存在残留肌层浸润。在近二倍体（1.8c - 2.2c）肿瘤中有17例（17%）、非整倍体肿瘤中有11例（38%）出现肌层浸润（p < 0.05）。未发现平均S期比率与肌层浸润之间存在统计学相关性。腔内治疗后非整倍体肿瘤与近二倍体肿瘤之间残留肌层浸润的差异可能反映了肌层浸润倾向的原发性差异或对放疗反应性的差异。
