Zhou S L, Meng B, Ding J H
Department of Respiration,Jiaxian People's Hospital,Jiaxian,467100，China.
Department of Respiration,Henan Traditional Chinese Medicine Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 May 5;31(9):690-693. doi: 10.13201/j.issn.1001-1781.2017.09.010.
To investigate the clinical significance of detecting peripheral blood hepatocyte growth factor（HGF） in OSAHS patients.Ninety-six cases of OSAHS patients in our hospital were selected as OSAHS group,and were divided into 3 subgroups according to the PSG results：mild,medium and severe. Each group included 32 cases,Thirty-five cases of healthy persons were selected as control group. ELISA method was utilized to detect the HGF level of peripheral blood. HGF concentration was measured in 32 patients with severe OSAHS after 3 months of comprehensive treatment. The relationship between serum HGF and sleep respiration events was further analyzed. The HGF concentration of peripheral blood increased with the severity of OSAHS.The serum levels of HGF in the control,mild,medium and severe group were（487.75±46.74）pg/ml，（519.44±50.77）pg/ml，（753.52±58.91） pg/ml and（829.49±61.74）pg/ml,respectively. There were significant differences among groups（=117．733,<0.01). HGF concentration in peripheral blood of OSAHS patients was unrelated to sex,age,and BMI（>0.05）,and positively correlated with AHI,negatively correlated with LSaO₂（<0.01）. After comprehensive treatment,the serum HGF concentration and AHI in severe OSAHS group were significantly decreased,while LSaO₂ was significantly increased.The level of HGF was increased in OSAHS patients and was positively correlated with the severity of OSAHS. Determining the level of HGF in peripheral blood is important for evaluating the severity of OSAHS and the degree of vascular endothelial dysfunction,and assessing the risk of cardiovascular disease.
探讨检测阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者外周血肝细胞生长因子（HGF）的临床意义。选取我院96例OSAHS患者作为OSAHS组，根据多导睡眠图（PSG）结果分为3个亚组：轻度、中度和重度。每组32例，选取35例健康人作为对照组。采用酶联免疫吸附测定（ELISA）法检测外周血HGF水平。对32例重度OSAHS患者进行综合治疗3个月后测定HGF浓度。进一步分析血清HGF与睡眠呼吸事件的关系。外周血HGF浓度随OSAHS严重程度增加而升高。对照组、轻度、中度和重度组血清HGF水平分别为（487.75±46.74）pg/ml、（519.44±50.77）pg/ml、（753.52±58.91）pg/ml和（829.49±61.74）pg/ml。组间差异有统计学意义（F=117.733，P<0.01）。OSAHS患者外周血HGF浓度与性别、年龄和体重指数无关（P>0.05），与呼吸紊乱指数（AHI）呈正相关，与最低血氧饱和度（LSaO₂）呈负相关（P<0.01）。综合治疗后，重度OSAHS组血清HGF浓度和AHI显著降低，而LSaO₂显著升高。OSAHS患者HGF水平升高，且与OSAHS严重程度呈正相关。测定外周血HGF水平对评估OSAHS严重程度和血管内皮功能障碍程度以及评估心血管疾病风险具有重要意义。
