Strang P, Stendahl U, Lindgren A, Sténson S
Department of Oncology, Uppsala University, Akademiska Sjukhuset, Sweden.
In Vivo. 1987 Mar-Apr;1(2):109-12.
The DNA content and the S-phase rate of 26 cervical adenocarcinomas and 100 endometrial adenocarcinomas, determined by flow cytometry, were compared. Statistically significant differences in DNA patterns were found, although only pure adenocarcinomas were studied in both groups. Peri-diploid values (1.8c-2.2c) were less common in cervical adenocarcinomas (38%) than in endometrial carcinomas (65%) (p less than 0.05). Six (23%) of the cervical carcinomas and 8 (8%) of the endometrial carcinomas had two detectable stem lines. The mean S-phase rate was significantly higher in adenocarcinomas of the uterine cervix than in endometrial carcinomas (p less than 0.02). The dominance of aneuploid values, the high proportion of polyclonal tumors and the high S-phase rates of the cervical adenocarcinomas have more similarities with the DNA patterns of cervical squamous cell carcinomas than with those of endometrial adenocarcinomas.
通过流式细胞术测定了26例宫颈腺癌和100例子宫内膜腺癌的DNA含量及S期比率，并进行了比较。尽管两组均仅研究了纯腺癌，但在DNA模式上发现了具有统计学意义的差异。近二倍体值（1.8c - 2.2c）在宫颈腺癌（38%）中比在子宫内膜癌（65%）中更少见（p < 0.05）。6例（23%）宫颈癌和8例（8%）子宫内膜癌有两条可检测到的干细胞系。宫颈腺癌的平均S期比率显著高于子宫内膜癌（p < 0.02）。宫颈腺癌的非整倍体值占优势、多克隆肿瘤比例高以及S期比率高，与宫颈鳞状细胞癌的DNA模式相比，与子宫内膜腺癌的DNA模式有更多相似之处。
